Renal involvement in primary antiphospholipid syndrome and its response to immunosuppressive therapy

• DOI: 10.1191/0961203303lu461oa
• Publication Date: 2003-11-12T12:45:16Z
• Authors: C Korkmaz; S Kabukcuoglu; S Isiksoy; A U Yalçin
• Keywords: Adult; Hypertension, Renal; Glomerulosclerosis, Focal Segmental; Antiphospholipid Syndrome; 3. Good health; Proteinuria; 03 medical and health sciences; 0302 clinical medicine; Pre-Eclampsia; Pregnancy; Azathioprine; Antibodies, Antiphospholipid; Humans; Female; Immunosuppressive Agents

Antiphospholipid syndrome (APS) is the association between antiphospholipid antibodies, venous and arterial thrombosis and pregnancy morbidity. Although the kidney may be affected in APS, the treatment of renal involvement is yet to be elucidated.This report describes the clinical and laboratory features of four patients with primary APS nephropathy, and the beneficial effect of immunosuppressive therapy accompanied by warfarin and angiotensin-convertingenzyme inhibitor. We also briefly discuss the possible mechanisms of the beneficial effects of immunosuppressiveson primary APS nephropathy.