Angioedema with haloperidol - case report

• DOI: 10.1192/j.eurpsy.2021.1284
• Publication Date: 2022-02-22T06:58:45Z
• Authors: A. Costa; S. Jesus; J. Alcafache
• Keywords: Psychiatry; 03 medical and health sciences; 0302 clinical medicine; RC435-571; Haloperidol; Angioedema; Anaphylactic reaction; Abstract; 3. Good health

Introduction Haloperidol is a high-potency first generation antipsychotic and one of the most frequently used medications. It potent central antagonist type 2 dopamine receptors, with low alpha 1 adrenergic activity has no antihistamine or anti-cholinergic activity. widely drug proven efficacy. Angioedema very rare side effect, occurring in <1% cases. Objectives Case report reflection on its etiology Methods A Pubmed search was performed MeSH terms “haloperidol” “Anaphylactic reactions”. Relevant articles obtained from respective bibliographic references were also consulted. Results The following case describes development angioedema patient an acute confusional syndrome second haloperidol IM administration for symptomatic control agitation. been reported as adverse effect various antipsychotics such clozapine, risperidone, ziprazidone chlorpromazine, however, resulting rare. Conclusions In long-term formulations sensitization testing especially important but single prior not sufficient, controlled essential to avoid this kind fatal reactions.