How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention

• DOI: 10.1192/j.eurpsy.2021.2253
• Publication Date: 2021-11-23T11:42:25Z
• Authors: Mario Luciano; Gaia Sampogna; Mario Amore; Ileana Andriola; Pietro Calcagno; Claudia Carmassi; Valeria Del Vecchio; Liliana Dell’Osso; Giorgio Di Lorenzo; Barbara Gelao; Vincenzo Giallonardo; Alessandro Rossi; Rodolfo Rossi; Alberto Siracusano; Andrea Fiorillo
• Keywords: lifestyle; Bipolar Disorder; Settore MED/25 - PSICHIATRIA; RC435-571; HOMA-IR index; Comorbidity; 796; BMI; 03 medical and health sciences; 0302 clinical medicine; Humans; BMI; Comorbidity; Framingham risk score; HOMA-IR index; RCT; lifestyle; severe mental disorders; waist circumference; Humans; Life Style; Bipolar Disorder; Mental Disorders; Psychotic Disorders; Schizophrenia; Life Style; Psychiatry; 2. Zero hunger; BMI; Comorbidity; Framingham risk score; HOMA-IR index; lifestyle; RCT; severe mental disorders; waist circumference; Mental Disorders; waist circumference; 3. Good health; Psychotic Disorders; BMI; Comorbidity; Framingham risk score; HOMA-IR index; lifestyle; RCT; severe mental disorders; waist circumference; Humans; Life Style; Bipolar Disorder; Mental Disorders; Psychotic Disorders; Schizophrenia; Schizophrenia; severe mental disorders; Framingham risk score; RCT; Research Article

Abstract Background People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, decade of years life lost. In this randomized controlled trial (RCT), we assessed in sample people bipolar disorder, major depressive and schizophrenia spectrum efficacy an innovative psychosocial group intervention brief psychoeducational on patients’ body mass index (BMI), weight, waist circumference, Framingham HOMA-IR indexes. Methods This is multicentric RCT blinded outcome assessments carried out six Italian university centers. After recruitment patients were receive 6-month improve physical health or intervention. All recruited standardized assessment instruments at baseline after 6 months. Anthropometric parameters blood samples also been collected. Results Four-hundred diagnosis disorder (43.3%), other psychotic (29.9%), depression (26.9%) randomly allocated experimental ( N = 206) control 195). months, from reported significant reduction BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31–2.84; p < 0.001), weight (OR 4.78, CI: 0.80–28.27, 0.05), circumference 5.43, 1.45–20.30, 0.05). Participants impaired cognitive functioning had worse response Conclusions The was effective improving SMI patients. Further studies are needed evaluate feasibility real-world settings.