Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

• DOI: 10.1192/j.eurpsy.2023.2411
• Publication Date: 2023-05-31T05:35:17Z
• Authors: Isabel Baenas; Romina Miranda-Ol...; Roser Granero; Neus Solé-Morata; Isabel Sánchez; Antoni Pastor; Amparo del Pino-G...; Ester Codina; Francisco J. Tina...; José A. Fernández...; Núria Vilarrasa; Fernando Guerrero...; Rafael Lopez-Urdi...; Núria Virgili; Carles Soriano-Mas; Susana Jiménez-Mu...; Rafael de la Torre; Fernando Fernánde...
• Keywords: Anandamide; Anorexia nervosa; Binge-eating disorder

Abstract Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food energy metabolism. Aberrant functioning of the endocannabinoid system has been observed extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] obesity without eating disorders [EDs]) compared healthy controls (HCs), its association clinical variables body mass index (BMI). Methods The sample included 113 adult women. Fifty-seven belonged group, 37 EDs (OB-ED) 20 ED (OB+ED classified within binge spectrum disorders), 27 from AN 29 HC group. Peripheral blood samples, several variables, BMI were evaluated. Results Unlike 2-AG, showed significant differences between groups ( p < 0.001). Increased was OB-ED OB+ED both respectively. Likewise, differentially associated emotional dysregulation, general psychopathology, addiction, all groups. Conclusions These results support interaction biological factors contributing delineating vulnerability pathways that could help fit personalized therapeutic approaches.