GWAS in interaction with childhood traumas implicates novel variants and genes previously associated with suicide-related factors in the background of suicidal ideation

• DOI: 10.1192/j.eurpsy.2024.695
• Publication Date: 2024-08-27T09:10:45Z
• Authors: X. Gonda; S. Krause; B. Erdelyi-Hamza; S. Sutori; Z. Gal; N. Eszlari; G. Bagdy; G. Juhasz; D. Torok
• Keywords: Genome-wide Association Study

Introduction Although suicide claims more lives than war and homicide, we still have no sufficient effective methods either for its prediction or prevention. Our screening are laborous subjective both on the side of patient clinician. Understanding genetic background suicidal behaviour would help identify biomarkers as well pathways potential targets novel intervention prevention approaches. However, in spite a number GWAS studies, results few rarely replicate, generally accurate phenotyping consideration environmental stressors is also missing. Objectives In our present study performed genome-wide analysis ideation interaction with early childhood traumas deep-phenotyped general population sample. Methods used data from 1800 volunteers NewMood project. As outcome phenotype item Brief Symptom Inventory was used. A modified version Childhood Trauma Questionnaire to assess adverse experiences. association Plink 1.9, including total 3,474,641 variants after quality control steps, followed by environment analyses. models included variables sex, age, top 10 genomic principal components. Functional annotation SNPs carried out using FUMA v1.5.6, gene-based tests were MAGMA v1.08. Results 7 met suggestive significance main effect analyses, which 2 reached rs79912020 (p=3.21E-10, β=0.746) rs10236520 (p=1.71E-08, β=0.484), significant findings tests. Interaction analyses adversities yielded 31 that significance, rs7983955 (p=2.28E-11, β=0.182), rs141039461 (p=3.90E-11, β=0.0541), rs12692827 (p=3.69E-10, β=0.0612) SNPs. adversities, genes showed tests, RBFOX1 (p=1.09E-10), GRM7 (p=1.20E-10), MTCH1 (p=5.59E-09), CDH13 (p=6.60E-09) most findings. Conclusions indicate several important associated when considered adversities. Furthermore, replicate playing key role central nervous system function such (encoding metabotropic glutamate receptor 7) previously implicated ( ) suicide-related factors aggression ). Funding: NAP2022-I-4/2022, K143391, 2019-2.1.7-ERA-NET-2020-00005, TKP2021-EGA-25 Disclosure Interest None Declared