Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity

• DOI: 10.1194/jlr.m300522-jlr200
• Publication Date: 2004-06-08T00:30:42Z
• Authors: Helena Gylling; Maarit Hallikainen; Jussi Pihlajamäki; Jyrki Ågren; Markku Laakso; Radhakrishnan A. ...; Rainer Rauramaa; Tatu A. Miettinen
• Keywords: Lathosterol; Cholestanol; Desmosterol

The roles of polymorphisms the sitosterolemia genes ABCG5 and ABCG8 in regulation cholesterol metabolism insulin sensitivity were studied mildly hypercholesterolemic noncoronary subjects (n = 263, 144 men 119 women) divided into tertiles by baseline serum cholestanol-to-cholesterol ratio (≤118.3 ≥147.7 10² × mmol/mol cholesterol), a surrogate marker absorption efficiency. lowest cholestanol tertile was associated with high body mass index (BMI), plasma glucose, triglycerides, synthesis markers (cholestenol, desmosterol, lathosterol) low HDL (campesterol, sitosterol) (<i>P</i> <0.01 for all). 19H allele gene accumulated < 0.001) total LDL 0.05 604E BMI, insulin, sitosterol, cholestenol levels In subgroup 71 men, resistance measured hyperinsulinemic euglycemic clamp. conclusion, efficiency characteristics metabolic syndrome. Low linked to D19H polymorphism gene, syndrome Q604E gene.