Pathologic Characteristics of Patients in the Kamuzu Central Hospital Lymphoma Study (2013-2019)

• DOI: 10.1200/go.22.13000
• Publication Date: 2022-05-05T18:31:01Z
• Authors: Morgan Dewey; Amy Lilly; Matthew Painschab; Tamiwe Tomoka; Yuri Fedoriw
• Keywords: Concordance; Telepathology

PURPOSE We evaluated the concordance of lymphoproliferative disorder (LPD) diagnoses made initially at Kamuzu Central Hospital (KCH) with a limited immunohistochemistry panel and telepathology consultation University North Carolina (UNC) Chapel Hill second review UNC an extensive available. METHODS The prospective KCH Lymphoma Study in Lilongwe has been enrolling patients LPDs since 2013. Diagnoses are by pathologists Malawi supported US Malawian clinicians weekly conferences. Diagnostic tissue blocks sent quarterly to for secondary further confirmatory studies. Concordance diagnosis from primary was scored as: exact match (level 1), differences granularity 2), change classification but not treatment 3), that would have altered course (Major Discordance). Cases insufficient were excluded evaluation. RESULTS Three hundred eighty-eight adult enrolled (June 2013-May 2019). twenty-seven 292 diagnostic samples had sufficient quality review. five most common diffuse large B-cell lymphoma (n = 143, 49%), Burkitt (9%, n 25, 8%), classical Hodgkin (8%, 23), Multicentric Castleman disease low grade non-Hodgkin (6%, 17). Level 1, 2 3 represented 175 (60%), 49 (17%) 50 cases, respectively, Major Discordance identified 18 cases (6%). CONCLUSION With limited, selected consultation, 94% accurately classified real-time, leading appropriate therapy. evaluation provides measure assurance program, confidence involvement interventional trials, useful data understanding epidemiology Malawi.