Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a Pediatric Oncology Group study.

• DOI: 10.1200/jco.1998.16.5.1723
• Publication Date: 2017-02-24T09:44:47Z
• Authors: R K Mulhern; J L Kepner; P R Thomas; F D Armstrong; H S Friedman; L E Kun
• Keywords: Pediatric Oncology; Childhood Cancer

PURPOSE The purpose of this study was to test the hypothesis that survivors medulloblastoma who were younger at diagnosis and those received standard-dose cranial irradiation (SRT) 36 Gy would have a lower performance on standardized tests cognitive function achievement than children older treated with reduced-dose (RRT) 23.4 Gy. PATIENTS AND METHODS Eligible patients had been Pediatric Oncology Group (POG) 8631 for low-risk randomized receive RRT or SRT after surgical resection. Those alive free progressive disease 6.1 9.9 years from completion treatment eligible study. Of 35 patients, 22 (13 SRT, nine RRT) participated in battery included intellectual academic development as well ratings health-related quality life. RESULTS Patients stratified by group (SRT v into (Y) (O) groups median age (8.85 years), which resulted four we hypothesized show neuropsychologic scores following order: Y/SRT less Y/RRT O/SRT O/RRT. Evidence support ordering terms toxicity obtained regard Performance Intelligence Quotient (IQ), Full Scale IQ, Attention, Reading, Arithmetic. CONCLUSION Children experienced severe when instead irradiation. Older time