Prognostic Significance of Vascular Endothelial Growth Factor Protein Levels in Oral and Oropharyngeal Squamous Cell Carcinoma

• DOI: 10.1200/jco.2000.18.10.2046
• Publication Date: 2017-02-24T09:23:15Z
• Authors: Benjamin D. Smith; Grace L. Smith; Darryl Carter; Clarence T. Sasaki; Bruce G. Haffty
• Keywords: Adult; Male; Lymphokines; Chi-Square Distribution; Neovascularization, Pathologic; Endothelial Growth Factors; Middle Aged; Prognosis; Disease-Free Survival; 3. Good health; Cohort Studies; Immunoenzyme Techniques; Oropharyngeal Neoplasms; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Carcinoma, Squamous Cell; Humans; Female; Mouth Neoplasms; Neoplasm Recurrence, Local; Aged; Proportional Hazards Models

PURPOSE: Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in many different tumor types. VEGF levels may affect growth, metastatic potential, and response to radiotherapy. This study assesses the prognostic value of protein a cohort patients with oral oropharyngeal squamous cell carcinomas. The relationships between clinical outcome covariables tumor-node-metastasis stage, disease stage (I IV), grade, margin status, race, sex, age were also determined. PATIENTS AND METHODS: Chart review identified 77 or carcinoma treated gross total surgical resection postoperative radiation 1981 1992. Sufficient follow-up data tissue available 56 (73%). determined using immunohistochemistry. association covariables, was assessed bivariate multivariate model two-sided statistical tests. RESULTS: Twenty-three tumors (41%) positive for expression. VEGF-positive more likely recur locally (relative risk [RR] = 3.08; 95% confidence interval [CI], 1.03 9.24) distantly (RR 4.62; CI, 1.41 15.10). In analysis, positivity most significant predictor poor disease-free survival 2.66; 1.27 5.56) overall 3.21; 1.63 6.32). 2.75; 1.30 5.79) 3.53; 1.75 7.13). CONCLUSION: this cohort, prognosis. status prove be an important factor head neck cancer.