Extranodal Natural Killer T-Cell Lymphoma, Nasal-Type: A Prognostic Model From a Retrospective Multicenter Study

• DOI: 10.1200/jco.2005.04.1384
• Publication Date: 2005-12-28T01:13:52Z
• Authors: Jeeyun Lee; Cheolwon Suh; Yeon Hee Park; Young H. Ko; Soo Mee Bang; Jae Hoon Lee; Dae Ho Lee; Jooryung Huh; Sung Yong Oh; Hyuk-Chan Kwon; Hyo Jin Kim; Soon Il Lee; Jung Han Kim; Jinny Park; Seok Joong Oh; Kihyun Kim; Chulwon Jung; Keunchil Park; Won Seog Kim
• Keywords: International Prognostic Index; Prognostic variable

Purpose Patients with natural killer T (NK/T) -cell lymphomas have poor survival outcome, and for this condition there is no optimal therapy. The purpose of study was to design a prognostic model specifically extranodal NK/T-cell lymphoma, which can identify high-risk patients who need more aggressive Methods This multicenter retrospective comprised 262 were diagnosed lymphoma. Results After median follow-up duration 51.2 months, 5-year overall rate in 49.5%. Prognostic factors “B” symptoms (P = .0003; relative risk, 2.202; 95% CI, 1.446 3.353), stage .0006; 2.366; 1.462 3.828), lactate dehydrogenase (LDH) level .0005; 2.278; 1.442 3.598), regional lymph nodes .0044; 1.546; 1.009 2.367). Of patients, 219 had complete information on four parameters. We identified different risk groups: group 1, adverse factor; 2, one 3, two factors; 4, three or factors. new showed superior discrimination as compared the International Index (IPI). Notably, distribution balanced when adopted (group 27%; 31%; 20%; 22%), whereas 81% categorized low low-intermediate risks using IPI. Conclusion newly proposed lymphoma demonstrated into groups better