Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma-In-Situ: Ten-Year Results of European Organisation for Research and Treatment of Cancer Randomized Phase III Trial 10853—A Study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group

• DOI: 10.1200/jco.2006.06.1366
• Publication Date: 2006-06-27T00:54:15Z
• Authors: Nina Bijker; Philip Meijnen; Johannes L. Peterse; Jan Bogaerts; Irène Van Hoorebeeck; Jean-Pierre Julien; Massimiliano Gennaro; Philippe Rouanet; Antoine Avril; Ian S. Fentiman; Harry Bartelink; Emiel J. Th. Rutgers
• Keywords: Adult; Salvage Therapy; 0301 basic medicine; Analysis of Variance; Breast Neoplasms; Middle Aged; Mastectomy, Segmental; Disease-Free Survival; 3. Good health; Europe; 03 medical and health sciences; Carcinoma, Intraductal, Noninfiltrating; Mastectomy, Modified Radical; Risk Factors; Humans; Female; Radiotherapy, Adjuvant; Neoplasm Recurrence, Local; Aged; Follow-Up Studies; Proportional Hazards Models

The European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role radiotherapy (RT) after local excision (LE) ductal carcinoma-in-situ (DCIS) breast. We analyzed efficacy RT with 10 years follow-up on both overall risk recurrence (LR) related to clinical, histologic, treatment factors.After complete LE, women DCIS were randomly assigned no further or (50 Gy). One thousand ten mostly (71%) mammographically detected included. median was 10.5 years.The 10-year LR-free rate 74% in group treated LE alone compared 85% by plus (log-rank P < .0001; hazard ratio [HR] = 0.53). invasive LR reduced 48% (P .0011) 42% .0065) respectively. Both groups had similar low risks metastases death. At multivariate analysis, factors significantly associated an increased young age (< 40 years; HR 1.89), symptomatic detection (HR 1.55), intermediately poorly differentiated (as opposed well-differentiated DCIS; 1.85 1.61 respectively), cribriform solid growth pattern clinging/micropapillary subtypes; 2.39 2.25 doubtful margins 1.84), 1.82). effect homogeneous across all assessed factors.With long-term follow-up, continued reduce LR, 47% reduction at years. All patient subgroups benefited from RT.