Risk of Hospitalization According to Chemotherapy Regimen in Early-Stage Breast Cancer

• DOI: 10.1200/jco.2013.49.3676
• Publication Date: 2014-05-28T06:47:44Z
• Authors: Carlos H. Barcenas; Jiangong Niu; Ning Zhang; Yufeng Zhang; Thomas A. Buchholz; Linda S. Elting; Gabriel N. Hortob...; Benjamin D. Smith; Sharon H. Giordano
• Keywords: Regimen; Chemotherapy regimen

Purpose To compare the risk of hospitalization between patients with early-stage breast cancer who received different chemotherapy regimens. Patient and Methods We identified 3,567 older than age 65 years from SEER/Texas Cancer Registry-Medicare database 9,327 younger MarketScan were diagnosed 2003 2007. The selection was nonrandomized nonprospectively collected. categorized according to regimens they received: docetaxel (T) cyclophosphamide (C), doxorubicin (A) C, TAC, AC + T, dose-dense paclitaxel (P) or weekly P. compared rates chemotherapy-related hospitalizations that occurred within 6 months initiation used multivariable logistic regression analysis identify factors associated these hospitalizations. Results Among years, ranged 6.2% (dose-dense P) 10.0% (TAC), those TAC T had significantly higher did TC. 12.7% (TC) 24.2% (TAC) AC, P Conclusion highest in years. all (aside a may be affected by biases where less aggressive are offered frailer patients.