Primary versus interval debulking surgery and the risk to induce platinum resitance.

• DOI: 10.1200/jco.2014.32.15_suppl.5588
• Publication Date: 2019-01-03T17:33:44Z
• Authors: Alexandre Andre B...; Camila Vieira Val...; Augusto Saito; Adriana Regina G....; Milena Tariki; Andrea Paiva G. G...; Solange Sanches; Celso Lopes Mello; Julio Cesar Prestes; Maria Isabel Wadd...
• Keywords: Debulking

5588 Background: Interval debulking surgery (IDS) is an option to treat patients with stage IIIC and IV ovarian carcinoma. Two randomized trials have shown similar survival for primary sugery (PDS) IDS. One of the concerns IDS potentialy higher risk induce platinum resistance when treating larger disease volume. At least one retrospective analysis sugest that treated a develop at second relapse. Methods: We did retroscpective review medical records from 213 carcinoma single institution 2000 2013. analysed association baseline clinical pathological characteristics time first resistant relapse (TTPR), resitant relapse, defined as free interval (PFI) after line chemotherapy less than 6 months, overall response rate (ORR) sensitive Results: For median follow-up 58.6 was 45.2 months progression 18.3 months. Factors related shorter TTPR in univariate were residual (RD) > 10mm surgery, CA 125>150 before treatment (chemotheray or surgery) compared PDS. In multivariate cox regression model including these three variables age (IIIC vs IV), RD>10mm (HR 1.87, CI95% 1.37-2.44, p<0.001) 3.39, 1.31-8.81, p=0.012) 1.79, 1.02-3.18, p=0.043) remained associated TTPR. The only factor greater PFI<6 (OR 1.59, 1.14-2.20, p=0.005) worse ORR 4.32, 1.15-16.15, p=0.030. Conclusions: may be induction. Some bias choosing PDS not been accounted this due its nature, but it supports hypotesis other papers suggests would interesting see done clincal already published.