T-cell primary central nervous system lymphoma: A systematic literature analysis.

• DOI: 10.1200/jco.2014.32.15_suppl.e13034
• Publication Date: 2019-01-03T22:27:24Z
• Authors: Hung Vo; Ashmeet Bhatia; Edwin Lok; Eric T. Wong
• Keywords: Presentation (obstetrics)

e13034 Background: Primary central nervous system lymphoma (PCNSL) is a rare form of extranodal non-Hodgkin’s confined primarily to the system. T-cell PCNSLs comprise less than 4% all and they appear have worse prognosis B cell PCNSLs. The incidence rising due to, in part, better neuroimaging modalities. objective this study was gain more depth understanding clinical presentation disease treatment outcomes that may affect patient survival. Methods: A systematic review literature performed using PubMed database from 1983 2013. Search conducted for case descriptions PCNSL. Inclusion criteria consisted articles having detailed information age, gender, location tumor treatment. Results: Of 200 citations reviewed, 90 were identified with PCNSL majority them reports or series, total number patients being 136. There 16 cases reported between years 1980-1990, 54 1990-2000, 66 2000-2013. Men outnumber women by ratio 2:1. median age 42.5 (range 2 79) overall survival (OS) 14.0 (95% CI 13.3 20.1) months those ≤64 compared 8.0 4.8 14.1) >64 (P=0.0033). Fifty-one received methotrexate-based chemotherapy only 46% achieved complete response (CR). no difference Kaplan-Mier diagnosed solitary versus multiple tumors (χ2=0.3, P=0.6090), treated not-treated methotrexate (χ2=0.1, P=0.7420), CR non-CR status after therapy (χ2=0.4, P=0.5470). Conclusions: Compared historical data, appears be aggressive responsive HV AB contributed equally.