A pyrolytic compound of curcumin, a dietary deketene curcumin to inhibit gastric carcinogenesis in a mouse model.

• DOI: 10.1200/jco.2017.35.15_suppl.e15518
• Publication Date: 2018-09-06T15:43:28Z
• Authors: Taichi Yoshida; Masahiro Inoue; Koji Fukuda; Kazuhiro Shimizu; Daiki Taguchi; Hiroyuki Shibata
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

e15518 Background: Gastric cancer is the second cause of death in world, killing more than 700,000 people 2012. The risk factors are Helicobacter pyloriinfection, obesity, smoking, consumption red meat or alcohol. However, an effective preventive measure this disease has bot been established. Curcumin, a dietary pigment, that used for three thousand years, anti-tumor potential. bioavailability curcumin very poor, and it not clinics. Researchers trying to overcome short point. To synthesize new analog bearing higher potential our solution, we have successfully developed series diarylpentanoid analogs. Our analogs structurally different from curcumin, diarylheptanoid. Recently, breakthrough finding deketene formed as result pyrolysis during cooking curry, was published. This identical one analogs, 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one, named GO-Y022. For reason, investigate efficacy safety issues GO-Y022 mouse gastric model. Methods: We assessed on cell lines, KATO Ⅲ, H-111-TC, GCIY SH-10-TC. also examined inhibit β-Catenin pSTAT3 levels. conducted experiment using transgenic model overexpressing Wnt signaling, COX2 Prostaglandin E2. highly seceptible carcinogenesis. orally administrated mixed with food. checked treated mouse, measured tissue concentration by HPLC method. Results: can growth lines significantly. average IC 50 value 5.05 ± 0.93 μm. That about five times lower curcumin. confirmed mice. Blood distribution were negligible except gastrointestinal epithelia. safe models. Conclusions: carcer vivo. Oral administration suppress gastic topically.