Prognostic value of BAP1 expression in clear cell renal cell carcinoma with inferior vena cava tumor thrombosis.

• DOI: 10.1200/jco.2017.35.15_suppl.e16080
• Publication Date: 2018-09-06T15:45:33Z
• Authors: Suguru Oka; Naoko Inoshita; Yuji Miura; Ryosuke Oki; Yu Miyama; Shoichi Nagamoto; Kohei Ogawa; Kazushige Sakaguchi; Chihiro Kondoh; Kazuhiro Kurosawa; Shinji Urakami; Toshimi Takano; Toshikazu Okaneya
• Keywords: BAP1; Metastasectomy

e16080 Background: Renal cell carcinoma (RCC) is characterized by a propensity for extension into the renal vein and inferior vena cava (IVC), affected patients have poor prognosis. BAP1 mutation, which occurs in about 15% of with clear RCC (ccRCC), also predicts The aim this study was to elucidate association between expression clinicopathologic outcomes ccRCC an IVC tumor thrombus. Methods: Thirty-nine thrombus who underwent radical nephrectomy thrombectomy at our institution from 1999 2010 were retrospectively evaluated. Immunohistochemical analyses performed BAP1, associations clinical assessed. Survival using Kaplan–Meier method log-rank test. Multivariate overall survival (OS) variables Cox proportional hazard model. For all analyses, P < 0.05 considered statistically significant. Results: median follow-up time 58.8 months (range, 2–130 months). age 66 years 37–80 years). Four (10.3%) had lung metastasis initial diagnosis. primary right-sided 27 (69.2%) left-sided 12 (30.8%). extended above below diaphragm 11 (28.2%) 28 (71.8%) patients, respectively. KPS score > 80 23 (59.0%). positive 26 (67.0%) cases negative 13 (33.0%). BAP1-negative tumors associated significantly shorter OS than BAP1-positive (median OS, 42.0 vs. 81.5 months, respectively; = 0.019). disease-free -positive 10.0 19.0 respectively (P analysis showed that only status 0.026). Conclusions: A prognosis thrombectomy.