Changes in blood parameters of patients with laryngeal squamous cell carcinoma during polychemotherapy with cetuximab.

• DOI: 10.1200/jco.2017.35.15_suppl.e17579
• Publication Date: 2018-09-06T15:47:30Z
• Authors: Liubov Yu Vladimi...; Nailya Guskova; Ludmila A. Ryadin...; Marina Engibaryan; Aliya K. Donskaya; Ekaterina Guskova; Marina A. Gusareva; Nadezhda Golomeeva; Svetlana V. Abaku...; Irina V. Tselishc...; Kristina Avanesova; Anastasia Nozdric...; Viktoria Zakharch...; Svetlana V. Belgova; Ekaterina Gornost...
• Keywords: White blood cell

e17579 Background: Our purpose was to evaluate changes in blood parameters patients with laryngeal squamous cell carcinoma (LSCC) during polychemotherapy (PCT) cetuximab. Methods: Levels of white cells (WBC), immature granulocytes (IG) and neutrophils (Ne), as well levels C-reactive protein (CRP), lactate dehydrogenase (LDH) creatinine were studied the 20 stage I-III LSCC before therapy cetuximab/cisplatin+5-fluorouracil on days 2, 9 16 therapy. The control group (21 patients) received similar PCT without Treatment assessed using RECIST criteria. Results: Partial response observed (80%) main 5 (23.8%) controls, stabilization - 4 (20%) 12 (57.4%), respectively, progression – (19%) group. Patients treatment effect showed WBC increase by 2 times after every cetuximab injection (days 9, 16) compared initial due Ne IG 2.7 times, respectively. measured 13.40±2.86×10 /L, 13.52±1.88×10 12.25±2.08×10 /L 0.044±0.021×10 0.056±0.015×10 0.060±0.008×10 respectively (p < 0.001). A transient indexes replaced their decrease values, values reference ones end treatment. At same time, we CRP up (7.69±3.28 mg/L 74.75±6.54 umol/L, respectively); LDH did not increase. Stabilization characterized unchanged levels, positive dynamics slow decline level exceeding one (10.0 mg/L) end. Reduction noted controls regardless results which could be explained severity intoxication syndrome, partially disease toxicity. Conclusions: dual reduction indicate minimization myelotoxic general toxic effects combination