The rates of ABO, Rh, and Kell antigens in children with cancer.

• DOI: 10.1200/jco.2017.35.15_suppl.e22007
• Publication Date: 2018-09-06T15:55:35Z
• Authors: Andrey A. Maslov; Nailya Guskova; Ekaterina Guskova; Kristina Avanesova; Svetlana V. Belgova; Ekaterina Gornost...; Irina V. Tselishc...; Viktoria Zakharch...; Izabella Torpudzhyan; Aliya K. Donskaya; Marina A. Gusareva; Svetlana V. Abaku...; Nadezhda Golomeeva; Anastasia Nozdric...
• Keywords: H antigen

e22007 Background: The purpose of the study was to analyze phenotypic characteristics red blood cells by AVBO, Rh and Kell systems in children with cancer. Methods: ABO groups were determined erythrocyte antigens (D, С, с, С w , Е, е, К, k) typed (AutoVue Innova, USA) samples 114 solid tumors. Results: distribution as follows: A(II) > O(I) B(III) AB(IV) prevalence. Rh(D)-positive phenotype observed 82 (71.9%) patients 114: 47 (57.3%) boys 35 (42.6%) girls. 32 (28.1%) Rh(D)-negative: 15 (46.8%) 17 (53.1%) Only 8 (7%) Kell-positive, which similar antigen prevalence European population. 4 phenotypes most frequent patients: СсDееK− (34.1%), ССDееK− (22.0%), ccDEeK− (13.4%) СсDЕеK− (11.0%). I.e., more than a half oncopathologies (56.1%) had Kell-negative phenotypes, ССDееK−. 86.4% homozygous combinations Rhesus causing transfusion reactions - СС, сc, ЕЕ ее. 18 (22.0%) for C 64 (78.0%), i.e. every third patient, c antigen. Children may be sensitized through subsequent development hemolytic complications. K (Cellano) found all children, 93% them kk 7% Kk. (Willis) revealed only 5 (6.0%) rare CceeK-, ccEeK-, CcEEK-, CcEeK-. Matching donor one these could pose problem. Conclusions: Studying is necessary providing successful transfusion, especially Kell-positive antigen, ССDееК- СсееК-, ссЕеК-, СсЕЕК- СсЕеК- phenotypes.