Formation of FcRγ-deficient NK cell subset associated with HCMV-reactivation in hematopoietic cell transplant recipients.

• DOI: 10.1200/jco.2017.35.7_suppl.131
• Publication Date: 2019-11-26T17:54:27Z
• Authors: Jaewon Lee; Sungjin Kim; Jeannine Scott; A. Samer Al-Homsi; Stephanie F. Will...; Marlee Muilenburg; Suyeon Hong; Walter J Esselman
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

131 Background: We have previously identified a novel subset of human NK cells that lacks FcRγ, transmembrane signaling adaptor associated with CD16, the Fc receptor for IgG. These FcRγ-deficient (termed g-NK cells) display enhanced functional activity against target cells, including virus-infected in concert target-specific antibody molecules. The presence humans is prior infection by cytomegalovirus (HCMV). Additionally, are activated and expand robustly HCMV-infected HCMV-specific antibodies, consistent predicted features memory-like or adaptive cells. Recent studies reported expansion specific an phenotype can occur response to HCMV reactivation after hematopoietic cell transplantation. Remarkably, patients expanded showed reduced incidence leukemia relapse improved disease-free survival. Methods: Using blood samples obtained from BMT pre- post-transplant, we performed FACS-based phenotyping ELISA-based serotyping analyses explore whether HCMV-reactivation correlates generation bone marrow transplantation (BMT) setting. Results: Our data demonstrate appear transplant following HCMV-reactivation, but not without HCMV-reactivation. Phenotypic analysis indicates these characteristics those observed healthy HCMV-seropositive individuals, e.g. decreased expression tyrosine kinase SYK. Conclusions: results provide evidence support causal relationship between Given capability formation within may contribute control during procedure, impact recovery other diseases.