Postsurgical multiple-sites sampling procedure for the precise detection of microvascular invasion of hepatocellular carcinoma.

• DOI: 10.1200/jco.2019.37.15_suppl.e15657
• Publication Date: 2019-05-27T16:08:36Z
• Authors: Qian Zhou; Lili Chen; Shuling Chen; Qinghua Cao; Sui Peng; Bing Liao; Ming Kuang
• Keywords: 0202 electrical engineering, electronic engineering, information engineering; 02 engineering and technology; 3. Good health

e15657 Background: Microvascular invasion (MVI) is an important risk factor of recurrence for hepatocellular carcinoma (HCC). We aimed to explore the relationship number sampling sites (NuSS) and location with positive rate MVI, investigate cut-off values NuSS. Methods: From May 2010 Feb 2017, 910 HCC patients undergone hepatectomy well-preserved tissue blocks were retrospectively enrolled. Associations between NuSS rates MVI investigated. The thresholds according different factors determined by Chow test Breakpoints function, validated prospectively in 118 patients. In validation cohort, locations estimated. Results: increased as ( P < 0.001). Tumor size two influencing A minimum four, six, eight required detecting solitary tumors measuring 1.0-3.0 cm, 3.1-4.9 cm ≥ 5.0 multiple tumors. per developed significantly higher all tumor subgroups cohort than those routine clinical practice training (46.7% vs. 20.6%, P= 0.048; 44.4% 24.4%, 0.025; 73.3% 50.3%, 0.004; 67.7% 45.4%, 0.026). interface proximal distal paracancerous normal liver parenchyma. Conclusions: number, distribution provided evidences standardized sample collection cancer specimen accurate diagnosis.