Delirium incidence, risk factors, and treatment in older adults receiving chemotherapy: A scoping review.

• DOI: 10.1200/jco.2019.37.15_suppl.e23025
• Publication Date: 2019-05-28T13:58:45Z
• Authors: Shabbir M.H. Alibhai; Patrick Jung; Zuhair Alam; Lily Yeung; Uzair Malik; Ali Taqi Syed; Carla Rosario; Daniel Yokom; Leigha Rowbottom; Ana Patricia Ayala; Roger Reka; Martine Puts
• Keywords: CINAHL; Data extraction

e23025 Background: Older adults with cancer are at increased risk of delirium given their advanced age, multiple comorbidities and medications, prevalence cognitive impairment, possibly treatment. Awareness such risks interventions to prevent or treat is important clinicians provide high quality care. However, there scant published information on the chemotherapy evidence-based approaches it. We performed a scoping review summarize available evidence. Methods: conducted using framework Arksey O’Malley. systematically searched peer-reviewed journal articles in English, French, German from Medline, Embase, PsychINFO, CINAHL Plus, Cochrane Central inception until January 2017 identify studies that examined patients receiving chemotherapy. also attempted any reported multivariable prediction models clinical trials prevention treatment delirium. Article titles abstracts as well full text were reviewed Covidence software by two more reviewers independently. Similarly, data extraction was independent reviewers. Results: A total 21,678 screened, 1,166 full-text reviewed. Nineteen varying study designs (retrospective administrative databases trials) an acceptable diagnostic standard. Sample sizes varied 15 over 21,000. No one tumour site protocol constituted majority studies. The incidence ranged 0 51% (mean 13.5%). time course relative cycle inconsistently reported. for delirium, no intervention identified. An additional 109 outcomes could be part syndrome but did not meet even our broad inclusion criteria (e.g. disturbance). Conclusions: Delirium may occur 1 8 older chemotherapy, although substantial limitations This highlights dearth knowledge area, particularly factors, prevention, treatment, emphasizes need high-quality examining these oncology setting.