The comparison of tumor microenvironment characteristics of well-differentiated and dedifferentiated liposarcoma and the association between immune cell infiltrations and recurrence of tumor.

• DOI: 10.1200/jco.2022.40.16_suppl.11569
• Publication Date: 2022-06-06T17:43:03Z
• Authors: Yuhong Zhou; Weiqi Lu; Zhengqing Song; Ding Zhang; Yanan Chen; Lili Lu; Qiwen Zhou; Wenshuai Liu; Yang You; Chenlu Zhang; Xi Guo; Yuan Fang; Zhiming Wang; Hanxing Tong; Rongyuan Zhuang; Yong Zhang
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

11569 Background: Well-differentiated liposarcoma (WDLPS) and dedifferentiated (DDLPS) are common malignancies of adipocytic origin, which in different differentiation stages. Both them characterized by high local recurrence rate. The tumor microenvironment (TME) is associated with the prognosis immune-related cell infiltrations has been proved to be one mechanisms affecting efficacy immunotherapy. However, difference between TME characteristics WDLPS DDLPS as well association immune WD/DDLPS not fully studied. Methods: 37 Chinese patients were enrolled this study, including 24 13 DDLPS. Tissue samples from these examined, who experienced previous or no recurrence. density percentage subsets identified multiplexed immunohistochemistry multispectral imaging. Twenty lines derived our center used analyze correlation cells content patient tissues lines. Results: Overall, had more than WDLPS. Compare WDLPS, CD8+ (the cytotoxic T identification) CD163+ (M2 macrophages FOXP3+ (Treg was significantly DDLPS, a Wilcoxon p-value 0.02, 0.04 0.03, respectively. There significant other protein markers According multiple cut-off values (tertiles, quintile tenths) cells, Chi-square test results equally suggested PD-1+ (Wilcoxon p = 0.02), while fewer 0.04) without those Patients CD3+ total infiltrations, although both statistically significant. CD4+ Treg distributed for once, but less two In addition, strong observed analysis. Conclusions: Our findings that might benefit immunotherapy due infiltrating increase times lead repressive liposarcoma.