Randomized trial of diet and exercise on chemotherapy completion in women with breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) study.

• DOI: 10.1200/jco.2022.40.16_suppl.12007
• Publication Date: 2022-06-06T17:44:07Z
• Authors: Tara B. Sanft; Maura Harrigan; Brenda Cartmel; Fangyong Li; Michelle Zupa; Courtney McGowan; Leah M. Ferrucci; Leah Puklin; Thai Hien Nguyen; Anna Tanasijevic; Marian L. Neuhouser; Dawn L. Hershman; Karen Basen-Engquist; Beth A. Jones; M. Tish Knobf; Anees B. Chagpar; Andrea Silber; Jennifer A. Ligibel; Melinda L. Irwin
• Keywords: Clinical endpoint

12007 Background: In observational studies, 25%-55% of women with breast cancer (BC) do not complete chemotherapy as initially prescribed, primarily due to toxicity. Relative dose intensity (RDI) is an integrated measure delays and reductions associated mortality. Physical activity (PA) diet may reduce treatment toxicity, but less known about their effect on RDI. We conducted a randomized trial PA intervention RDI (primary endpoint) in newly diagnosed BC initiating chemotherapy. Methods: 173 Stage I-III were usual care (UC, n = 86) or yearlong, 16-session, in-person telephone-administered (n 87) delivered by registered dietitians. Dates, doses reason for dose-adjustments/delays abstracted from electronic medical records obtained treating oncologists. T-tests Chi-square tests used examine the vs. UC Results: Participants 53±11 years old, had body mass index 29.7+6.8 kg/m 2 , 51% stage I 22% under-represented minorities. 27 different regimens prescribed. completed 94% counseling sessions during statistically significant improvements compared UC. Average continuous was unexpectedly high both groups, 93%+14% prescribed (p 0.92). However, 17% 15% participants, respectively, < 85% 0.70) more than one-third at least one toxicity-associated reduction and/or delay (> 7 days) drug (39% 37% UC, p 0.80). posthoc analyses, there benefit completion 74 receiving neoadjuvant (RDI: 95% 90% 0.05). Among women, dose-response seen participants who achieved better quality via Healthy Eating Index (above median) experiencing higher vs below median (97% RDI, Conclusions: A telephone-based led improved PA, did improve observed Future analyses will effects secondary endpoints endocrine therapy adherence patient-reported outcomes when all reach 1-year timepoint (end intervention). Further study interventions patients are necessary. Clinical information: NCT03314688.