Implications of HPV infection on survival outcomes in patients with penile squamous cell carcinoma: Insights from a nationwide study.

• DOI: 10.1200/jco.2024.42.16_suppl.5045
• Publication Date: 2024-06-06T17:58:12Z
• Authors: Rohan Garje; Mohammad Arfat Ga...; Atulya Aman Khosla; Shahzaib Ahmad; Vivek Podder; Shreyas S Bellur; Diya Jayram; Karan Jatwani; Manmeet Singh Ahl...
• Keywords: Penile Carcinoma

5045 Background: Human Papilloma Virus (HPV) infection is a favorable prognostic marker in certain cancers, particularly oropharyngeal and vulvar (SCC). Patients with pSCC have risk profile clinical course like pSCC. However, the impact of HPV status on survival remains uncertain. Methods: We conducted retrospective study using National Cancer Database included patients tested for between 2004-2021. Survival outcomes were analyzed reported as median overall (mOS, 95% CI). Multivariate analysis adjusting age, disease stage, treatment modalities, comorbidities, was performed Cox proportional hazards models hazard ratios (HR, Results: Out 1371 men pSCC, 539 (39.3%) positive (HPV +ve). At diagnosis, most +ve presented early-stage cancer(I-III), 6% stage IV. The mOS 123.96 months (98.96 - 148.40) vs. 104.38 (89.13 115.98) negative (P=0.01). In adjusted analysis, presence associated HR death 0.79 (0.65-0.98; P = 0.03) compared to without (table). Conclusions: improved survival. These findings highlight Indicator irrespective profile. Therefore, testing at time diagnosis should be routinely [Table: see text]