Efficacy of a combined diet and exercise intervention in patients with breast cancer undergoing chemotherapy: A meta-analysis of randomized controlled trials.

• DOI: 10.1200/jco.2024.42.16_suppl.e12517
• Publication Date: 2024-07-03T19:06:03Z
• Authors: Maria Meritxell R...; Luisa Marin Cunha; Angelina Kozhokar...; Farhan Afzal; Amanda Godoi
• Keywords: 03 medical and health sciences; 0302 clinical medicine

e12517 Background: Breast cancer treatment presents challenging side effects that may compromise patients’ health and quality of life (QoL). While exercise programmes have been shown to improve survival, the impact combined dietary interventions compared usual practices alongside chemotherapy remains controversial. Methods: PubMed, Embase, Cochrane Central, ClinicalTrials.gov were systematically searched up October 2023. We included randomized controlled trials (RCTs) involving adult breast patients undergoing comparing diet with care. Outcomes interest weight change, relative dose intensity (RDI), Functional Assessment Cancer Therapy-General scale (FACT-G) score for QoL. Statistical analysis was performed using Review Manager 5.4.1 RStudio version 4.1.2. The protocol registered on PROSPERO (ID: CRD42023463543). Results: Seven RCTs 960 therapy included, whom 506 (53%) assigned interventions. Participants had a mean BMI 26.6 kg/m 2 , approximately 52% postmenopausal. Combined resulted in significant reductions loss (MD -1.06 kg, 95% CI -1.68 -0.44; p<0.01), -1.76 -0.13; body fat -2.12%; -3.99 -0.26; p=0.03), FACT-G -3.40; -6.25 -0.55; p=0.02) No differences observed waist circumference (p=0.05), RDI (p=0.23), or fatigue levels (p=0.98) between groups. Conclusions: In this meta-analysis trials, improved management but did not significantly completion, levels, worsened Findings can help further holistic care, taking into account both physical psychosocial dimensions patient health.