Expanding diversity in colorectal cancer studies with a focus on Hispanic and Latino participant enrollment.

• DOI: 10.1200/jco.2024.42.16_suppl.e13532
• Publication Date: 2024-05-29T17:43:22Z
• Authors: Syed K Lateef; Kanza Chaudhary; Karolina Kutnik; Yontao Lu; Chuanbo Xu; Lilian C. Lee; Lance Baldo; Aasma Shaukat; Theodore R. Levin
• Keywords: Outreach

e13532 Background: Colorectal cancer (CRC) is a leading cause of mortality among Hispanic and Latino groups (Hispanic/Latinx). Despite making up 18.9% the U.S. population, Hispanic/Latinx representation only 2.3%-3.9% subjects in oncology trials, highlighting need for diversity CRC research. Freenome developing blood test (MyTectCRC) intended to provide convenient accessible option screening. Its clinical validation will be supported by PREEMPT CRC, prospective multi-center observational study. To ensure diverse enrollment, partnered with several sites, including IHS, communities population. This analysis explores strategies used at IHS Health effectively enroll minority groups. Methods: Initiated 2020, study (NCT04369053) enrolled participants aged 45-85 average risk. Eligible consenting underwent draw screening colonoscopy (CS), sample analyzed using investigational test. Health, research institute Kissimmee, Florida, utilized variety methods maximize enrollment populations reflective its local communities, such as partnering organizations establish community outreach employing bilingual staff translate, educate, answer questions, cultural sensitivity. Participants were also able have drawn undergo CS on same day due proximity gastroenterology office. Results: The site 427 study, substantial (78.7%) which exceeded their proportional self-reported race was predominantly White (71.2%), significant proportion Black or African American (24.1%). age distribution showed higher 65-74 group, emphasizing inclusivity older characteristic catchment area. exhibited healthy lifestyle behavior majority population abstaining from tobacco (88.8%), alcohol (84.1%) drug use (99.5%). very receptive test/CS all undergoing 96% adherence. Conclusions: results underscore success Health's recruitment addressing health disparity importance high Hispanic/Latinx, demographics. Success highlights careful selection, robust strategies, practical accessibility patients comprehensive understanding medical interventions across populations. Clinical trial information: NCT04369053 .