Esophageal cancer in the United States: A 21-year mortality analysis (1999-2020).

• DOI: 10.1200/jco.2024.42.16_suppl.e23258
• Publication Date: 2024-06-03T21:01:26Z
• Authors: Muhammad Zain Farooq; Usama Kamal; Adeena Jamil; Eeshal Fatima; Abiha Khurram; Zoha Khan; Zainab Kamdi; Sana Ahmed; Michael Vishal Ja...
• Keywords: 03 medical and health sciences; 0302 clinical medicine

e23258 Background: Esophageal cancer (EC) is the sixth leading cause of cancer-related deaths in United States, with a mere 20% survival rate first five years, making it significant public health concern. Considering lack comprehensive evaluations mortality trends that are undergoing substantial transformations on global scale, this study aims to provide an update rates esophageal and its States. Methods: The among adults EC were analyzed using data from Centers for Disease Control Prevention Wide-Ranging Online Data Epidemiological Research (CDC WONDER) database, where was presented as contributing or underlying death. Code C15 “Malignant Neoplasms Esophagus” International Classification Disease, tenth revision (ICD-10) used identify data. Crude age-adjusted (AAMRs) per 100,000 people extracted. Annual percent changes (APCs) AAMRs 95% CI obtained joint point regression analysis across different demographic (sex, race/ethnicity, age) geographic (state, urban-rural, regional) subgroups. Results: Between 1999 2020, 309,725 documented attributed cancer. overall AAMR decreased 1999-2020 (6.69 5.68). Males had higher consistently than females (10.96 vs. 2.24). NH White highest (6.88), followed by Black (6.46), American Indian (4.95), Hispanic Latino (3.31), Asian Pacific Islander (2.57). CMRs also increased advancing age greatest individuals over 85 years. varied region (overall AAMR: Midwest: 7.18; Northeast: 6.75; South: 6.07; West: 5.76), non-metropolitan areas (non-core areas: 7.09; micropolitan 7.19) metropolitan (large central 5.75; large fringe 6.33). states upper 90th percentile Vermont, District Columbia, West Virginia, Ohio, New Hampshire, Maine, exhibited approximately two-fold increase AAMRs, compared falling lower 10th percentile. Conclusions: Over last two decades, there has been decline related However, discrepancies EC-related persist, necessitating additional exploration development specifically directed treatments.