Survival in advanced prostate cancer (PCa) patients with visceral metastasis: A population-based SEER study.

• DOI: 10.1200/jco.2025.43.5_suppl.134
• Publication Date: 2025-02-18T14:35:11Z
• Authors: Salman Ayub Jajja; Syed Arsalan Ahme...; Muhammad Ali Khan; Muhammad Umar Afzal; Muhammad Umair Anjum; Ammad Raina; Prateek Jain; Fnu Swati; Zaryab Bin Riaz; Daniel S Childs; Ewan Kemar Cobran; Alan Haruo Bryce; Yousef Zakharia; Parminder Singh; Irbaz Bin Riaz

134 Background: Prostate cancer patients with visceral metastases at diagnosis are often treated using one-size-fits-all approach. For example, CHAARTED criteria treats any metastasis as high volume. Therefore, we aimed to assess overall survival (OS) by site of involvement in metastatic PCa. Methods: Surveillance, Epidemiology, and End Results (SEER) database (2010-2021) was queried obtain case listing data on PCa from 17 registries. The were categorized into three groups based diagnosis: lung metastasis, liver others. Kaplan-Meier analysis performed estimate median OS 95% confidence interval (CI). Log-rank test conducted if significantly different among the groups. Cox proportional hazard regression magnitude difference P-value <0.05 established statistical significance. Results: This included 21,007 (lung: n=319; liver: n=123; brain: 107; bone: 20538). Metastatic population exhibited a 60 months (95% CI: 48-72) compared 24 12-36) 36 36-36) other metastases. statistically significant (p < 0.001). Compared those (HR: 1.91; 1.41-2.57) but not (1.16; 0.97-1.39) had worse adjusting for Gleason score, PSA race (Table). Conclusions: In PCa, lung-only have better should be considered differently prognostication Consideration is critical treatment intensification decisions. Limitations this include lack accounting confounding relationships individual patient level. Variable Hazard Ratio CI) Metastases (Lung) REFERENCE (Liver) 1.91 (1.41-2.57) (Other) 1.16 (0.97-1.39) score≥8 score <8 0.68 (0.64 -0.72) - ng/dL 1.01 (1.00 – 1.01) Race (White) (Black) 0.99 (0.94 1.05) (Asian or Pacific Islander) 0.70 0.76)