Impact of liquid biopsies on early detection, monitoring, and prognostication in prostate cancer: A meta-analysis of emerging evidence.

• DOI: 10.1200/jco.2025.43.5_suppl.32
• Publication Date: 2025-02-18T14:32:56Z
• Authors: Muhammad Nabeel S...; Atif Hussain Sarwar; Hashim Talib Hashim; Ahmed Qasim Moham...; Sheena Shamoon

32 Background: Prostate cancer remains a leading cause of cancer-related morbidity and mortality among men worldwide. Traditional diagnostic monitoring techniques often lack sensitivity specificity, particularly in early stages. Liquid biopsies, which analyze circulating tumor cells (CTCs) DNA (ctDNA) from blood samples, have emerged as promising non-invasive alternative for detection, disease progression, prognostication prostate cancer. Methods: The PubMed, Embase, Scopus Cochrane databases were systematically searched inception until June 2024 using relevant keywords. We analyzed the pooled data untransformed proportions with 95% confidence intervals (CI) Random Effects model OpenMeta (version 5.3). I 2 X statistics used to evaluate inter-study heterogeneity. An value >50% was considered significant Subgroup analyses performed assess accuracy, prognostic value, clinical utility CTCs ctDNA. Results: A total 30 studies involving 5,200 patients included meta-analysis. biopsies demonstrated 85% (95% CI: 80%-90%) specificity 88% 83%-92%) detection ctDNA levels significantly correlated burden, Gleason score, metastatic potential. Furthermore, elevated associated poorer overall survival progression-free survival, underscoring their value. Conclusions: offer robust, method monitoring, This meta-analysis highlights potential improve outcomes through timely accurate management. Future research should focus on standardizing methodologies integrating liquid into routine practice.