Early detection of recurrent prostate cancer using 18F-DCFPyL PET/CT PET/CT in patients with minimal PSA levels.

• DOI: 10.1200/jco.2025.43.5_suppl.344
• Publication Date: 2025-02-18T14:33:57Z
• Authors: Ida Sonni; Nicholas George N...; Katelyn Niknam; Gholam Reza Berenji; Derace Schaffer; Louis Montagut; Karl Sjöstrand; Aseem Anand; Matthew Rettig
• Keywords: PET-CT; Recurrent prostate cancer

344 Background: PSMA PET imaging is a highly sensitive and specific tool for detecting prostate cancer, especially in biochemical recurrence (BCR). This has led to growing interest utilizing patients with minimally detectable PSA levels following definitive treatment as conventional rarely localizes recurrent disease this range, potentially delaying diagnosis appropriate management. However, there limited literature on the detection rate of 18F-DCFPyL at very low BCR setting. Methods: pooled retrospective analysis from investigator-initiated trials West Los Angeles Veterans Affairs phase III CONDOR trial minimal levels. Patients included had PET/CT values (0.05 0.5 ng/ml). was defined rising were irrespective prior findings. The scan reads assisted by automated Prostate Cancer Molecular Imaging Standardized Evaluation (aPROMISE) platform. results verified an experienced independent nuclear medicine physician. Primary focused number positive lesions relative total BCR. Results: In 129 identified, 36 ranging 0.05 0.2 ng/ml, 93 >0.2 ng/ml. site findings, intensity volume uptake are detailed table below. Conclusions: demonstrates high cancer even levels, highlighting its potential valuable early identification metastatic disease. These findings suggest that current thresholds initiating may need reconsideration optimize subsequent clinical Further studies necessary refine guidelines assess cost-effectiveness incorporating 0 – (N=36) (N=93) Total Detection Rate 13 (36%) 47 (51%) Bed 3 (8%) 4 (4%) Lymph Node Only 5 (14%) 29 (31%) Bone 12 (33%) 39 (42%) 8 (22%) 14 (15%) Visceral (Lung or Liver) 1 (3%) 10 (11%) SUVmean 3.8 4.2 SUVmax 10.9 12.4 (mean) 4.9 ml 1.9