Prognosis in metastatic renal cell cancer (mRCC) with major venous involvement (MVI): A population-based study.

• DOI: 10.1200/jco.2025.43.5_suppl.454
• Publication Date: 2025-02-18T14:42:46Z
• Authors: Ahsan Ayaz; Manahil Khan; Syed Arsalan Ahme...; Muhammad Umar Afzal; Ewan Kemar Cobran; Sajid Ahmad Mir; Haidar Abdul-Muhsin; Parminder Singh; Irbaz Bin Riaz; Yousef Zakharia

454 Background: Limited data exist on outcomes in mRCC patients with major venous involvement (MVI). Assessment of impact a given variable prognosis cancer is challenging competing causes death (PMID: 25417239). This analysis aims to estimate MVI, considering from causes. Methods: Data the Surveillance Epidemiology and End Results (SEER) database (2010-2020) were analyzed for survival mortality MVI. 5-year (y) overall (OS) 5-y probability calculated using actuarial method SEER*Stat 8.4.4, reported as percentages 95% confidence intervals (CI). based site MVI (renal vein, inferior vena cava [IVC]) stratified by age (<65, >65 years), gender (male, female), race/ethnicity (Non-Hispanic [NH] White, NH Black, Asian/Pacific Islander [API], Hispanic). Results: A total 89047 included our whom 10785 (12%) had Overall, who experienced worse compared those did not have (5-y OS: 53.2% vs 84.4% death: 38.6% 8.2% respectively). Among cohort was poor IVC renal vein 36% 57%; 56% 35% Patients worst older adults (>65 y) 47.8%; 40.8%) Black 41.5%; 49.8%) (Table). Conclusions: Prognosis especially involvement, poor, particularly patients. Further research needed better prognostication risk stratification improve high-risk Subgroup No N OS (%), CI Cancer Overall population 78,262 84.4 (84.1-84.7) 8.2 (8.0-8.4) 10,785 53.2 (52.0-54.3) 38.6 (37.5-39.7) Age <65 y 49,217 89.0 (88.6-89.2) 6.5 (6.3-6.8) 5,897 57.5 (56.0-59.0) 36.8 (35.4-38.3) 29,045 77.0 (76.1-77.2) 10.9 (10.5-11.4) 4,888 47.8 (46.0-49.5) 40.8 (39.2-42.4) Gender Male 49,221 83.0 (82.7-83.5) 8.9 (8.6-9.2) 7,503 (51.8-54.6) 38.3 (37.0-39.6) Female 29,041 86.5 (86.0-86.9) 7.0 (6.7-7.4) 3,282 53.0 (51.0-55.0) 39.4 (37.4-41.3) Race/ethnicity White 49,520 84.0 (83.7-84.4) 8.3 (8.0-8.5) 7,182 53.5 (52.1-54.8) 38.0 (36.7-39.3) 8,878 82.0 (81.0-82.9) 8.1 (7.5-8.8) 685 41.5 (37.1-45.9) 49.8 (45.4-54.1) API 4,747 86.0 (85.1-87.4) 8.5 (7.6-9.4) 713 52.9 (48.2-57.3) 39.9 (35.5-44.1) Hispanic (All Races) 13,826 (85.8-87.2) 7.9 (7.4-8.4) 2,014 56.2 (53.4-58.8) 36.7 (34.1-39.2) N: number cases; survival; CI: interval; NH: Non-Hispanic; API: Islander; MVI: involvement.