Racial disparities in secondary metastasis in patients with bladder cancer: A 5-year National Inpatient Sample study.

• DOI: 10.1200/jco.2025.43.5_suppl.671
• Publication Date: 2025-02-18T14:43:07Z
• Authors: Sakditad Saowapa; Natchaya Polpichai; Manasawee Tanariy...; Chalothorn Wannaphut; Chanakarn Kanitth...; Hector J Garcia P...; Diego Alonso Olav...; Watsachon Pangkanon; Vivie Tran; Pharit Siladech; Lukman Aderoju Ti...

671 Background: Bladder cancer is one of the most common cancers globally, with significant variations in disease outcomes observed across racial groups. Secondary metastasis plays a critical role determining prognosis and overall survival bladder patients. However, disparities metastatic progression remain underexplored. This study aims to investigate how race influences patterns patients using large national database. Methods: A retrospective analysis National Inpatient Sample (NIS) from 2016 2020 was performed identify adults diagnosed ICD-10 codes. Patients were categorized based on presence metastasis. Multivariable logistic regression models used assess impact secondary key organ systems, including lung, liver, bone, brain, while adjusting for potential confounders. Caucasians as reference group, statistical significance defined p-values ≤ 0.05. Results: The cohort included 411,360 cancer, whom 66,805 (16.2%) had mean age significantly lower (71.00 years, 95% CI: 70.78–71.22) compared those without (74.02 73.90–74.14) (p < 0.001). Racial observed, African American having higher odds lung (OR 1.23, 1.11–1.38, p 0.001) liver 1.18, 1.05–1.33, = 0.005). Asian more likely develop bone 1.29, 1.13–1.47, brain 1.46, 1.03–2.09, 0.036). Other factors associated risk radiation therapy 3.71, 2.16–6.38, 0.001), comorbidities like diabetes 0.64, hypertension 0.86, Conclusions: highlights showing systems Caucasians. These findings underscore need consider differences clinical management treatment strategies Further research required explore underlying causes these their long-term survival.