Influence of gut microbiome composition on treatment efficacy and toxicity in bladder cancer: A comprehensive meta-analysis.

• DOI: 10.1200/jco.2025.43.5_suppl.768
• Publication Date: 2025-02-18T14:40:47Z
• Authors: Atif Hussain Sarwar; Hashim Talib Hashim; Ahmed Qasim Moham...; Muhammad Nabeel S...; Sheena Shamoon
• Keywords: Gut microbiome

768 Background: The gut microbiome has emerged as a critical factor influencing the efficacy and toxicity of cancer treatments. In bladder cancer, variations in composition may affect patient responses to therapy, including immunotherapy chemotherapy. This meta-analysis aims comprehensively evaluate impact on treatment outcomes cancer. Methods: PubMed, Embase, Scopus Cochrane databases were systematically searched from inception until June 2024 using relevant keywords. pooled data presented Odds Ratio (OR) with 95% confidence intervals (CI) Random Effects model OpenMeta (version 5.3). I 2 X statistics used inter-study heterogeneity. An value >50% was considered significant subgroup analyses conducted identify specific profiles associated different responses. Results: A total 20 studies comprising 2,500 patients included meta-analysis. Patients higher abundance beneficial bacteria such Bifidobacterium Lactobacillus had significantly better (OR: 2.5, CI: 1.8-3.4) lower rates 0.6, 0.4-0.9). Conversely, an increased presence pathogenic like Clostridium Escherichia coli poorer 0.5, 0.3-0.8) 1.9, 1.3-2.7). Conclusions: highlights influence Identifying bacterial positive negative could guide personalized strategies improve care. Further research is needed understand mechanisms underlying these associations develop microbiome-targeted therapies.