Development of Corpus Callosum in Preterm Infants Is Affected by the Prematurity: In Vivo Assessment of Diffusion Tensor Imaging at Term-Equivalent Age

• DOI: 10.1203/pdr.0b013e3182084e54
• Publication Date: 2010-12-03T09:05:38Z
• Authors: Tatsuji Hasegawa; Kei Yamada; Masafumi Morimoto; Shigemi Morioka; Takenori Tozawa; Kenichi Isoda; Aki Murakami; Tomohiro Chiyonobu; Sachiko Tokuda; Akira Nishimura; Tsunehiko Nishimura; Hajime Hosoi
• Keywords: Splenium

Callosal injury in preterm infants is a key factor affecting neurodevelopmental outcome. We investigated the characteristics of corpus callosum (CC) without apparent white matter lesions. studied 58 divided into three groups 23-25, 26-29, and 30-33 wk GA. Diffusion tensor imaging (DTI) was obtained at term-equivalent age. The CC parcellated genu, body, isthmus, splenium. measured fractional anisotropy (FA) diffusion coefficient (ADC) each subdivision using tractography manual region interest analysis. cross-sectional areas were also measured. At isthmus splenium 23-25 GA group, FA significantly lower size reduced. Furthermore, posterior decreased linearly with decreasing There no differences other subdivisions, ADC any among groups. demonstrated that lesions affect development depending on degree prematurity.