Virtual Prototyping and Parametric Design of 3D-Printed Tablets Based on the Solution of Inverse Problem

• DOI: 10.1208/s12249-018-1176-z
• Publication Date: 2018-09-25T15:53:09Z
• Authors: Matěj Novák; Tereza Boleslavská; Zdeněk Grof; Adam Waněk; Aleš Zadražil; Josef Beránek; Pavel Kovačík; František Štěpánek
• Keywords: Fused Deposition Modeling; Rapid Prototyping

The problem of designing tablet geometry and its internal structure that results into a specified release profile the drug during dissolution was considered. A solution method based on parametric programming, inspired by CAD (computer-aided design) approaches currently used in other fields engineering, proposed demonstrated. forward using series structural motifs first carried out order to generate library profiles associated with each motif. inverse then solved three steps: first, combination basic whose superposition provides closest approximation required found linear pre-calculated profiles. In next step, final design constructed curve computationally. Finally, 3D printed confirmed experimentally. computational numerical diffusion boundary layer surrounding tablet, coupled erosion encoded phase volume function. tablets were fused deposition modelling (FDM) from filaments produced hot-melt extrusion. It could be effectively controlled modifying porosity. Custom obtained combining multiple porosity regions same tablet. yielded accurate predictions rate for both single- multi-porosity tablets.