Thyroid Hormone Regulates Oligodendrocyte Accumulation in Developing Rat Brain White Matter Tracts

• DOI: 10.1210/en.2004-0065
• Publication Date: 2004-07-16T00:26:31Z
• Authors: Christopher M. Sc...; Melissa M. Seibel; Dawn M. Jolson; Mary Jo Stack; Rounak J. Rahman; Sidney A. Jones; Cary N. Mariash; Grant W. Anderson
• Keywords: Anterior commissure; Commissure

Thyroid hormone (TH) is necessary for normal axonal myelination. Myelin basic protein (MBP) a structural essential myelin function. In this study, we demonstrate that perinatal hypothyroidism regulates MBP mRNA levels via indirect mechanisms. We observed decreased accumulation in the hypothyroid rat brain at postnatal (PN) d 10 and 50. Acute TH replacement did not rescue PN5, 10, or intrahemispheric commissure development including anterior (AC) corpus callosum (CC). determined decreases AC area cellularity developing by PN10 CC, initially increases but then ultimately PN50. MBP-expressing oligodendrocytes are recognized target of responsible myelination within commissures. found reduces number mature both CC. This reduction noted 50 Together, these data suggest through These complex mechanisms whereby brain.