Effect of Uncontrolled Diabetes on Plasma Ghrelin Concentrations and Ghrelin-Induced Feeding

• DOI: 10.1210/en.2004-0605
• Publication Date: 2004-07-15T20:26:31Z
• Authors: Richard W. Gelling; Joost Overduin; Christopher D. Mo...; Gregory J. Morton; R. Scott Frayo; David E. Cummings; Michael W. Schwartz
• Keywords: Orexigenic

Plasma levels of the orexigenic hormone, ghrelin, decrease rapidly on nutrient ingestion and yet are paradoxically elevated in rats with hyperphagia induced by streptozotocin-induced diabetes (STZ-DM). In current work, we investigated mechanisms underlying relationships among uncontrolled diabetes, food intake, plasma ghrelin concentrations an effort to clarify whether increased signaling contributes diabetic hyperphagia. Whereas intake did not increase until d 3 after STZ administration, were more than 2-fold (P < 0.05) 1. As developed, however, declined steadily. Because this reduction was reversed matching STZ-DM that nondiabetic controls, our results demonstrated effect is partially offset hyperphagic feeding. addition, found although intragastric infusion comparably decreased both groups (by 46-49%; P 0.05), short lived relative controls (60 min vs. 120 min; 0.05). We further STZ-DM, 357% response intracerebroventricular administration at a dose subthreshold for feeding effects controls. Collectively, these findings demonstrate increases circulating behavioral sensitivity ghrelin. Although fall feeding, support hypothesis pathogenesis