Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

• DOI: 10.1210/en.2008-0059
• Publication Date: 2008-05-23T00:53:35Z
• Authors: Hongfei Ge; Xiaofan Li; Jennifer Weiszmann; Ping Wang; Helene Baribault; Jin-Long Chen; Hui Tian; Yang Li
• Keywords: Male; Metabolic Syndrome; Mice, Knockout; 0301 basic medicine; Lipolysis; Down-Regulation; Mice, Obese; Fatty Acids, Nonesterified; Niacin; Receptors, G-Protein-Coupled; Mice, Inbred C57BL; Mice; 03 medical and health sciences; 3T3-L1 Cells; Adipocytes; Flushing; Animals; Propionates; Acetic Acid

G protein-coupled receptor 43 (GPR43) has been identified as a for short-chain fatty acids that include acetate and propionate. A potential involvement of GPR43 in immune inflammatory response previously suggested because its expression is highly enriched cells. also expressed number other tissues including adipocytes; however, the functional consequences activation these are not clear. In this report, we focus on functions adipocytes. We show adipocytes treated with natural ligands, propionate, exhibit reduction lipolytic activity. This inhibition lipolysis result activation, effect abolished isolated from knockout animals. mouse vivo model, by results plasma free acid levels without inducing flushing side observed nicotinic receptor, GPR109A. These suggest role regulating lipid profiles perhaps aspects metabolic syndrome.