Study of the Potential Association of Adipose Tissue GLP-1 Receptor with Obesity and Insulin Resistance

• DOI: 10.1210/en.2011-1070
• Publication Date: 2011-08-24T02:26:51Z
• Authors: Joan Vendrell; Rajaa El Bekay; Belén Peral; Eduardo García-Fu...; Anna Megia; Manuel Macias-Gon...; José Fernández Real; Yolanda Jimenez-G...; Xavier Escoté; Gisela Pachón; Rafael Simó; David M. Selva; María M. Malagón; Francisco J. Tina...
• Keywords: 0301 basic medicine; 2. Zero hunger; Glucagon-Like Peptide-1 Receptor; Glp-1; Type 2 diabetes mellytus; Obesity, Morbid; 3. Good health; Mice; 03 medical and health sciences; Adipose Tissue; Glucagon-Like Peptide 1; 3T3-L1 Cells; Adipocytes; Receptors, Glucagon; Animals; Humans; Prospective Studies; Insulin Resistance; Glucagon-like peptide 1; Cells, Cultured

The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. actions GLP-1 on β-cells and nervous digestive systems are well known. action this peptide adipose tissue (AT), however, is still poorly defined. Furthermore, no relationship been established between receptor (GLP-1R) AT obesity insulin resistance (IR). We provide evidence presence show that its mRNA protein expressions increased visceral depots from morbidly obese patients with high degree IR. Experiments 3T3-L1 cell line showed lipolytic lipogenic dose-dependent effect GLP-1. Moreover, stimulated lipolysis adipocytes receptor-dependent manner involving downstream adenylate cyclase/cAMP signaling. Our data also demonstrate expression GLP-1R correlated positively homeostasis model assessment index IR subjects. prospective studies carried out underwent biliopancreatic diversion surgery subjects levels AT, which indicates deficit tissue, were those whose sensitivity improved after surgery, suggesting potential amelioration Altogether these results indicate GLP-1/GLP-1R system represents another candidate improving patients.