Androgens Regulate Bone Marrow B Lymphopoiesis in Male Mice by Targeting Osteoblast-Lineage Cells

• DOI: 10.1210/en.2014-1822
• Publication Date: 2015-02-02T16:32:36Z
• Authors: Anna S. Wilhelmson; Alexandra Stubelius; Anna E. Börjesson; Jianyao Wu; Anna Stern; Stephen Malin; Inga-Lill Mårtensson; Claes Ohlsson; Hans Carlsten; Åsa Tivesten
• Keywords: Lymphopoiesis

Testosterone has profound immune-modulatory actions, which may be important for the sexual dimorphism in immune-related disorders, such as autoimmune diseases. A well-known effect of androgens is inhibition bone marrow B lymphopoiesis; however, a plausible target cell this not yet been presented. The aim study was to determine androgen-mediated regulation lymphopoiesis males. We confirm higher number cells male mice with global inactivation androgen receptor (AR) and these AR knockout (G-ARKO) had increased precursors from pro-B stage. Because osteoblast-lineage are known support at stage, we investigated on cell-specific ARKO (O-ARKO) mice; O-ARKO marrow, demonstrating that mimics pattern G-ARKO mice. By contrast, displayed only minor changes numbers splenic compartment compared G-ARKO. Further, moderately reduced trabeculae vertebrae, whereas cortical unaffected. In conclusion, exert inhibitory effects males by targeting cells. identification likely will contribute elucidation mechanisms modulate disorders.