Determinants of Insulin Sensitivity and Secretion in Very-Low-Birth-Weight Children

• DOI: 10.1210/jc.2003-031239
• Publication Date: 2004-03-04T20:53:04Z
• Authors: Rodrigo A. Bazaes; Angélica Alegría; Enrica Pittaluga; Alejandra Ávila; Germán Íñiguez; Verónica Mericq
• Keywords: Glucose tolerance test

In prepubertal children, low birth weight is related to reduced insulin sensitivity, particularly if a history of rapid postnatal gain present. We sought determine whether these associations were also evident in premature, very-low-birth-weight (VLBW) children. studied 60 VLBW children aged 5-7 yr (mean age 5.7 +/- 0.7 yr). Birth weights ranged from 690 1500 g 1195 31 g), with gestational ages between 25 and 34 wk (median 29 wk). A short iv glucose tolerance test was carried out assess fasting sensitivity glucose-stimulated secretion. The effects current body mass index, (SD scores), growth rates, indicators morbidity evaluated by analysis covariance. Twenty born small for age, 40 appropriate age. Ninety-eight percent them had attained height within target range. Children who lower than (homeostasis model assessment resistance index 1.24 0.17 vs. 0.94 0.08, P < 0.05). Moreover, SD scores correlated significantly homeostasis (r = -0.326, 0.01). This effect persisted after adjustment perinatal morbidity. addition, postload secretion during the early independently scores. Our findings cohort indicate that utero as well rates are independent determinants subsequent