Adiponectin Levels in the First Two Years of Life in a Prospective Cohort: Relations with Weight Gain, Leptin Levels and Insulin Sensitivity

• DOI: 10.1210/jc.2004-0792
• Publication Date: 2004-11-05T01:39:05Z
• Authors: Germán Iñiguez; Nestor Soto; Alejandra Avila; Teresa Salazar; Ken Ong; David Dunger; Verónica Mericq
• Keywords: Leptin; Male; Infant, Newborn; Infant; Weight Gain; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Infant, Small for Gestational Age; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Female; Adiponectin; Prospective Studies; Insulin Resistance

Adiponectin, a novel adipocytokine with insulin sensitizing properties, is inversely related to obesity and resistance in adults. We recently reported large variations weight gain sensitivity during the first year infants born small for gestational age (SGA) or appropriate (AGA). now determined whether adiponectin levels were postnatal growth prospective cohort followed from birth two years old (n = 85) (55 female/30 male, 65 SGA/20 AGA). Serum at one higher compared adults older children, decreased (21.6 ± 0.6 μg/ml) (15.7 0.7 (p < 0.05). At lower females (15.3 0.4 than males (16.4 0.05), but no gender difference was seen leptin levels. No differences between SGA AGA years. However, changes (r −0.310, p Changes positively both 0.450 r 0.500 respectively, Adiponectin unrelated years, nor change In multiple regression analysis, only age; omitting model, determinants of male 0.03), body 0.001), SD score 0.004). conclusion, fall serum life increasing greater infants, sensitivity.