Acute Sex Steroid Withdrawal Reduces Insulin Sensitivity in Healthy Men with Idiopathic Hypogonadotropic Hypogonadism

• DOI: 10.1210/jc.2007-0454
• Publication Date: 2007-08-29T02:34:17Z
• Authors: Maria A. Yialamas; Andrew A. Dwyer; Erin Hanley; Hang Lee; Nelly Pitteloud; Frances J. Hayes
• Keywords: Homeostatic model assessment; Insulin tolerance test; Glucose tolerance test; Homeostasis

Evidence suggests that testosterone (T) influences insulin sensitivity in men. The mechanism of this effect is unclear but thought to involve changes body composition.The aim study was determine whether acute sex steroid withdrawal decreases young, healthy men with idiopathic hypogonadotropic hypogonadism (IHH).This a 2-wk prospective study.The conducted at General Clinical Research Center.Twelve IHH (age 40.8 +/- 2.8 yr) were studied: 1) on hormone replacement normal T levels and 2) 2 wk after discontinuing therapy.Each evaluation comprised 75-g oral glucose tolerance test assessment (fasting levels, homeostatic model for resistance, Matsuda index) secretion (corrected response). Serum cortisol, leptin, adiponectin, free fatty acids, IL-6, C-reactive protein, TNF-alpha also measured.Body mass index unchanged (27.1 1.1 27.2 kg/m(2)). decreased from 529 65 28 8 ng/dl (P < 0.00005). Fasting increased 4.9 0.7 6.2 0.6 microU/ml = 0.005), resistance 1.07 0.2 1.4 1.01 11.0 2.3 7.5 0.05). There trend fasting increase, 86.7 1.3 90.8 1.7 mg/dl 0.09). IL-6 1.2 2.4 0.5 pg/ml 0.01), whereas 1.0 0.1 No other significant observed.1) Acute reduces young acuity the absence or leptin suggest steroids modulate apparent detectable composition.