Adipose Tissue Expression of the Glycerol Channel Aquaporin-7 Gene Is Altered in Severe Obesity But Not in Type 2 Diabetes

• DOI: 10.1210/jc.2007-0531
• Publication Date: 2007-06-14T05:08:05Z
• Authors: V. Ceperuelo-Mall...; M. Miranda; M. R. Chacón; N. Vilarrasa; A. Megia; C. Gutiérrez; J. M. Fernández-...; J. M. Gómez; E. Caubet; G. Frühbeck; J. Vendrell
• Keywords: Adult; Male; 2. Zero hunger; Sex Characteristics; 0303 health sciences; Subcutaneous Fat; Middle Aged; Aquaporins; Polymorphism, Single Nucleotide; Obesity, Morbid; Cohort Studies; 03 medical and health sciences; Diabetes Mellitus, Type 2; Gene Expression Regulation; Humans; Female; RNA, Messenger; Aged

Aquaporin-7 is required for efflux of glycerol from adipocytes and influences whole-body glucose homeostasis in animal studies.Our objective was to test the hypothesis that AQP7 gene expression levels may be affected by presence obesity type 2 diabetes humans.The study cohort consisted 12 lean, 22 nonseverely obese, 13 severely obese subjects. The 17 lean 39 diabetic patients. Circulating plasma soluble proteins monocyte chemoattractant protein-1, TNF receptors 1 2, IL-6 were measured. sc adipose tissue AQP7, MCP-1, IL-6, TNFalpha, PPARgamma, SREBP1c genes measured real-time PCR. mutation analysis performed.Severely women showed lower compared with (P < 0.001). Moreover, circulating concentration subjects, but no correlation observed. negatively related proinflammatory (for r = -0.203 P 0.044; -0.209 0.036). Concerning adipogenic factors, found positively determined PPARgamma mRNA (r 0.265; 0.012). did not show differences regarding diabetes.Expression down-regulated severe obesity. this channel diabetes.