The Effect of a High-Fat Meal on Postprandial Arterial Stiffness in Men with Obesity and Type 2 Diabetes

• DOI: 10.1210/jc.2010-0413
• Publication Date: 2010-07-08T02:50:06Z
• Authors: L. K. Phillips; J. M. Peake; X. Zhang; I. J. Hickman; O. Kolade; J. W. Sacre; B. E. Huang; P. Simpson; S. H. Li; J. P. Whitehead; J. E. Sharman; J. H. Martin; J. B. Prins
• Keywords: Adult; Male; Risk; obesity; 1303 Biochemistry; Wave reflection; 1308 Clinical Biochemistry; medical; 03 medical and health sciences; 0302 clinical medicine; Humans; Obesity; Aged; 2. Zero hunger; Healthy-subjects; diabetes; high fat meal; Middle Aged; Postprandial Period; Dietary Fats; 1310 Endocrinology; 3. Good health; Diabetes and Metabolism; 2704 Biochemistry; 2712 Endocrinology; arterial stiffness; Diabetes Mellitus, Type 2; Cardiovascular Diseases; Diet, Atherogenic; Vascular Resistance; Insulin-induced decreases; Blood-pressure; metabolism

Postprandial dysmetabolism is emerging as an important cardiovascular risk factor. Augmentation index (AIx) a measure of systemic arterial stiffness and independently predicts outcome.The objective this study was to assess the effect standardized high-fat meal on metabolic parameters AIx in 1) lean, 2) obese nondiabetic, 3) subjects with type 2 diabetes mellitus (T2DM).Male (lean, n = 8; obese, 10; T2DM, 10) were studied for 6 h after water control. Glucose, insulin, triglycerides, (radial applanation tonometry) measured serially determine incremental area under curve (iAUC).AIx decreased all three groups meal. A greater overall postprandial reduction seen lean T2DM compared (iAUC, 2251 +/- 1204, 2764 1102, 1187 429% . min, respectively; P < 0.05). The time return baseline significantly delayed (297 68 min) (161 88 min; There significant correlation between iAUC triglycerides (r 0.50; 0.05).Obesity associated attenuated decrease AIx. Subjects have preserved, but prolonged, suggests that may impact vascular dynamics. markedly different response observed those unexpected warrants additional evaluation.