Racial/Ethnic Differences in Sex Hormone Levels among Postmenopausal Women in the Diabetes Prevention Program

• DOI: 10.1210/jc.2012-2117
• Publication Date: 2012-11-05T13:55:14Z
• Authors: Catherine Kim; Sherita Hill Golden; Kieren J. Mather; Gail A. Laughlin; Shengchun Kong; Bin Nan; Elizabeth Barrett...; John F. Randolph
• Keywords: Blood Glucose; Estradiol; Dehydroepiandrosterone; Middle Aged; Metformin; Body Mass Index; 3. Good health; Postmenopause; 03 medical and health sciences; 0302 clinical medicine; 5. Gender equality; Sex Hormone-Binding Globulin; Glucose Intolerance; Ethnicity; Humans; Hypoglycemic Agents; Female; Testosterone; Life Style; Aged

Sex hormones may differ by race/ethnicity in postmenopausal women. Whether racial/ethnic differences also exist among those who are overweight and glucose intolerant is not clear. The objective of the study was to compare sex [non-Hispanic white (NHW), Hispanic, African-American (AA)] overweight, glucose-intolerant, This a secondary analysis randomized controlled trial. Participants included glucose-intolerant women participating Diabetes Prevention Program. Interventions intensive lifestyle modification (consisting diet physical activity) or metformin 850 mg twice day vs. placebo. Baseline levels 1-yr intervention-related changes SHBG, total bioavailable estradiol (E2), testosterone, dehydroepiandrosterone were measured. At baseline, using estrogen (n = 370), NHW had higher E2 testosterone than Hispanics independent age, type menopause, waist circumference, alcohol intake, current smoking. lower SHBG AA. users 310), AA after adjustment. 1 yr, estrogen, larger declines adjustment for above covariates, randomization arm. users, hormone did race/ethnicity. Among women, there significant baseline hormones.