Sequential Versus Continual Purified Urinary FSH/hCG in Men With Idiopathic Hypogonadotropic Hypogonadism

• DOI: 10.1210/jc.2014-3802
• Publication Date: 2015-04-01T14:35:20Z
• Authors: Manna Zhang; Guoyu Tong; Yanling Liu; Yiming Mu; Jianping Weng; Yaoming Xue; Zuojie Luo; Yuanming Xue; Lixin Shi; Xueyan Wu; Shouyue Sun; Yanhua Zhu; Ying Cao; Jie Zhang; Hong Huang; Ben Niu; Hong Li; Qinghua Guo; Yan Gao; Zhibin Li; Guang Ning; Dalong Zhu; Xiaoying Li
• Keywords: Adult; Male; Adolescent; Sperm Count; Hypogonadism; Middle Aged; Chorionic Gonadotropin; Drug Administration Schedule; 3. Good health; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Testis; Humans; Drug Therapy, Combination; Spermatogenesis; Urofollitropin; Follow-Up Studies

Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization spermatogenesis men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication frequent injections affect compliance.The aim this study was to determine efficacy sequential use highly purified urinary (uFSH)/hCG IHH.A randomized, open-label, prospective, controlled noninferiority trial 18-month follow-up conducted 9 tertiary hospitals.A total 67 Chinese IHH were randomly allocated into group A receiving continual uFSH (75 U, 3 times week) hCG (2000 twice injection B week every other months) injection.The primary outcome proportion subjects sperm concentration ≥ 1.0 × 10(6)/mL during 18 months. The between groups compared for noninferiority.Of patients, 17/33 (51.5%) uFSH/hCG 19/34 (55.9%) achieved concentrations 10(6)/mL. not inferior that (noninferiority, P = .008) by intention-to-treat analysis.The patients IHH.