Reversible inhibition by interferons alpha and beta of 125I incorporation and thyroid hormone release by human thyroid follicles in vitro.

• DOI: 10.1210/jcem.77.5.8077347
• Publication Date: 2014-01-08T11:57:58Z
• Authors: K Yamazaki; Y Kanaji; K Shizume; Y Yamakawa; H Demura; Y Kanaji; T Obara; K Sato
• Keywords: Alpha (finance)

When interferons (IFN-alpha-2a, IFN-alpha-2b, natural IFN-alpha and IFN-beta) were cultured with human thyroid follicles, each IFN inhibited TSH-induced function (125I incorporation release of 125I-T4) in a concentration-dependent manner. The minimal inhibitory effect was exerted at 1-10 U/ml. However, the reversible, no detected when IFNs removed from medium within 12 h. These vitro findings suggest that directly inhibits clinically attainable levels. since therapy would provoke only subtle dysfunction majority patients without preexisting autoimmunity.