Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis

• DOI: 10.1211/jpp.62.02.0012
• Publication Date: 2010-10-14T12:42:49Z
• Authors: Saburo Yoshioka; Atsuhide Hamada; Kohei Jobu; Junko Yokota; Masahide Onogawa; Shojiro Kyotani; Mitsuhiko Miyamura; Toshiji Saibara; Saburo Onishi; Yutaka Nishioka
• Keywords: Steatohepatitis; Eriobotrya; Steatosis; Malondialdehyde

Non-alcoholic steatohepatitis is associated with the deposition of lipid droplets in liver, and characterised histologically by infiltration inflammatory cells, hepatocellular degeneration liver fibrosis. Oxidative stress may play an important role onset deterioration non-alcoholic steatohepatitis. We previously reported that Eriobotrya japonica seed extract, extracted 70% ethanol, exhibited antioxidant actions vitro vivo. In this study, we examined effect extract a rat model steatohepatitis.The was given drinking water to fats being fed methionine-choline-deficient diet for 15 weeks.Increases alanine aminotransferase aspartate levels were significantly inhibited rats compared group on alone. Formation fatty also inhibited. Antioxidant enzyme activity tissue higher than diet-only peroxidation reduced received extract. Expression 8-hydroxy-2'-deoxyguanosine 4-hydroxy-2-nonenal lower group. former, transforming growth factor-beta collagen decreased.Thus, E. inflammation fibrosis, suggesting its usefulness treatment