25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men

• DOI: 10.1212/wnl.0b013e3181c7197b
• Publication Date: 2009-11-26T05:50:42Z
• Authors: Y. Slinin; M. L. Paudel; B. C. Taylor; H. A. Fink; A. Ishani; M. T. Canales; K. Yaffe; E. Barrett-Connor; E. S. Orwoll; J. M. Shikany; E. S. LeBlanc; J. A. Cauley; K. E. Ensrud
• Keywords: Quartile; Cognitive Decline; Odds

Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk decline. Methods: We measured 25(OH)D assessed function using Modified Mini-Mental State Examination (3MS) Trail Making Test Part B (Trails B) in cohort 1,604 men enrolled Osteoporotic Fractures Men Study followed them for an average 4.6 years changes function. Results: In model adjusted age, season, site, seemed to have higher odds impairment, but trend did not reach significance (impairment by 3MS: ratio [OR] 1.84, 95% confidence interval [CI] 0.81–4.19 quartile [Q] 1; 1.41, 0.61–3.28 Q2; 1.18, 0.50–2.81 Q3, compared Q4 [referent group; p = 0.12]; Trails B: OR 1.66, CI 0.98–2.82 Q1; 0.96, 0.54–1.69 1.30, 0.76–2.22 [ 0.12]). Adjustment age education further attenuated relationships. There was independent association between decline 3MS performance (multivariable 0.89–2.23 1.28, 0.84–1.95 1.06, 0.70–1.62 0.10]), no B. Conclusion: found little evidence associations level baseline global executive or incident 3MS= : Examination; 25(OH)D= D; BMI= body mass index; CI= interval; IADL= instrumental activities daily living; MrOS= Men; OR= ratio; PASE= Physical Activity Scale Elderly; Q= quartile; B=